Inclusion Criteria:

• 18 years of age or older.
• Understand the study procedures, be able to provide written informed consent to participate in the study, and have authorization for release of data, including personal health data and images, to the study Investigator, Sponsor, and regulatory authorities.
• Present for surveillance imaging due to increased risk for HCC, including either:
  • Diagnosis of cirrhosis based on at least one of the following:
    • Histology from a liver biopsy;
    • Ultrasound, CT, or MRI showing a cirrhotic liver combined with portal hypertension (as evidenced by the presence of intra-abdominal varices, or recanalized umbilical vein, or ascites) and/or splenomegaly. The imaging results must have been obtained within 5 years of study enrollment;
    • Liver stiffness ≥ 4.71 kPa by MR elastography or ≥ 12.1 kPa by vibration controlled transient elastography.
    • Presence of varices on endoscopy or imaging and presence of a chronic liver disease; OR
  • Non-cirrhotic subjects with chronic HBV infection (Hepatitis B surface antigen present for > 6 months).

Exclusion Criteria:

• Known cancer diagnosis (including active malignancy) within the past 5 years except for non-melanoma skin cancer.
• Chemotherapy and/or radiation therapy within 5 years prior to study enrollment.
• Child-Pugh class C liver function at the time of enrollment, except for those on the waiting list for transplant.
• Solid liver nodule >1 cm by ultrasound or elevated AFP (>100 ng/mL) in 12 months preceding the qualifying surveillance imaging visit without subsequent documentation of HCC negative or LI-RADS 1 by diagnostic CT/MRI.
• Females known to be pregnant at the time of enrollment.
• Illness that the Investigator believes poses a significant risk of mortality during the study period, including but not limited to:
  • Congestive heart failure with ejection fraction < 50%;
  • Chronic lung disease requiring supplemental oxygen;
  • History of recent stroke.
• Sustained virologic response (SVR) for HCV (undetectable HCV RNA 12 to 24 weeks after completion of antiviral therapy) for > 10 years prior to enrollment.
• Not able to have IV contrast for CT or MRI due to:
  • Allergy to IV contrast and unwilling or unable to receive IV contrast after pre-medication;
  • Estimated glomerular filtration rate < 35 mL/min and not on hemodialysis.

Eligibility last updated 12/9/21. Questions regarding updates should be directed to the study team contact.