Inclusion Criteria:

1. Male or female, ≥18 years of age at Screening.

2. Planned to undergo non-emergent CABG and/or cardiac valve surgery requiring CPB;
non-emergent surgery must allow for study drug infusion ≥24 but ≤48 hours prior to
surgery.

3. If female, subjects must use an effective method of birth control or abstain from
sexual relations with a male partner (unless has undergone tubal ligation or
hysterectomy or is at least 1 year postmenopausal) for the duration of their study
participation.

4. If male, subjects must use an effective method of birth control or abstain from sexual
relations with a female partner for the duration of their study participation, unless
the subject has had a vasectomy ≥6 months prior to infusion with study drug.

5. Willingness to comply with all study-related procedures and assessments.

Exclusion Criteria:

1. Surgery planned to occur < 24 hours from the start of study drug infusion.

2. Presence of acute organ dysfunction (AKI, acute decompensated heart failure, acute
respiratory failure, stroke, etc) as assessed by the Investigator at the time of
Screening.

3. Surgery to be performed without CPB.

4. Chronic kidney disease (CKD) requiring dialysis.

5. Hypokalemia and/or hypomagnesemia within 24 hours prior to study drug infusion;
electrolytes can be replenished if low.

6. Cardiogenic shock or requirement for inotropes, vasopressors, or other mechanical
devices, such as intra-aortic balloon pump (IABP).

7. Known history of cancer within the past 2 years, except for carcinoma in situ of the
cervix or breast, early-stage prostate cancer, or adequately treated non-melanoma
cancer of the skin.

8. Known or suspected sepsis at time of Screening.

9. Asplenia (anatomic or functional).

10. History of hemochromatosis, iron overload, or porphyria.

11. Known hypersensitivity or previous anaphylaxis to SnPP or FeS.

12. Female subject who is pregnant or breastfeeding.

13. Participation in a study involving an investigational drug or device within 30 days
prior to study drug infusion.

14. In the opinion of the Investigator, for any reason, the subject is an unsuitable
candidate to receive RBT-1.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 12/14/23. Questions regarding updates should be directed to the study team contact.