Inclusion Criteria:

• Male or female subjects ≥ 18 years of age.
• Histologic or cytologic evidence of NSCLC.
• Known KRAS G12C mutation.
• The subject must have received prior therapy with a KRAS G12C inhibitor and experienced progression.
• Must have received appropriate treatment with at least one prior systemic regimen, but no more than 3 prior regimens, for Stage 3B-C or 4 NSCLC.
• Measurable disease according to RECIST 1.1.
• An Eastern Cooperative Group (ECOG) performance status ≤ 1.
• Adequate organ function.
• Adequate recovery from toxicities related to prior treatments.
• Agreement to use highly effective method of contraceptive.

Exclusion Criteria:

• Prior chemotherapy, targeted therapies, radiotherapy, immunotherapy or treatment with an investigational agent within 14 days of receipt of study drug (within 6 weeks for nitrosoureas, mitomycin C and chest radiation; within 6 months prior to Cycle 1 Day 1 for chest radiation > 30Gy).
• History of prior malignancy, with the exception of curatively treated malignancies.
• Major surgery within 4 weeks (excluding placement of vascular access).
• Exposure to strong CYP3A4 inhibitors or inducers within 14 days prior to the first dose and during the course of therapy.
• Exposure to strong inhibitors of breast cancer resistance protein (BCRP) within 14 days prior to the first dose and during the course of therapy.
• Symptomatic brain metastases requiring steroids or other local interventions within the 2 weeks prior to initiation of therapy.
• Known SARS-Cov2 infection ≤ 28 days prior to first dose of study therapy.
• Known hepatitis B, hepatitis C, or human immunodeficiency virus infection that is active.
• Active skin disorder that has required systemic therapy within the past 1 year.
• History of rhabdomyolysis or interstitial lung disease.
• Concurrent ocular disorders.
• Concurrent heart disease or severe obstructive pulmonary disease.
• Subjects with the inability to swallow oral medications.

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 8/25/22. Questions regarding updates should be directed to the study team contact.