Workers Performance and Health Outcomes of Office Air Ventilation and Filtration Control


About this study

The purpose of this study is to determine the benefits of indoor air quality control interventions, such as enhanced air ventilation and filtration, on office workers' productivity, cognitive performance and health.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • ≥ 18 and ≤ 59 years of age.
  • BMI ≥ 18.5.
  • Indoor office workers employed full-time at the Mayo Clinic or another business within and around Rochester, MN.
  • Report working a desk-based job, such as clerical and administrative staff.
  • Fully vaccinated and boosted against COVID-19.
  • Be willing to not wear a mask while in the office module.
  • Allowed to work from home for at least a whole week (5 consecutive workdays in Background Work-from-Home Condition).
  • Able to relocate to the WLL office during the workday, complete work in an open office space, be present for 80% of the total study for four consecutive work weeks, and be able to complete at least 80% daily tasks.
  • Each workday, short personal meetings/calls and lunch break outside the office is allowed, but the participants should spend no less than 6 hours per day in the office.
  • Be able to provide informed consent.

Exclusion Criteria:

  • Individuals who are lactating, pregnant, or intend to become pregnant during the study.
  • Shift-workers.
  • Individuals who are taking medications (either prescribed or over-the-counter) which may affect mental status.
  • Drug (illegal or prescription narcotic), nicotine, or alcohol dependency.
  • Individuals diagnosed with pre-existing respiratory, neurological, or severe sleep disorders given their potential impact on study outcomes;.
  • Individuals who have medical conditions associated with higher risk for severe COVID-19 (

Note: Other protocol defined Inclusion/Exclusion Criteria may apply.

Eligibility last updated 11/16/23. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Bruce Johnson, Ph.D.

Open for enrollment

Contact information:

Preventive Heart Research Team

(507) 538-7425

More information


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