Imaging Integration Into Electroanatomic Mapping for Catheter Ablation Procedures of Ventricular Arrhythmias


About this study

The aim of the present study is to assess the use of high-resolution imaging data from CT and or MRI processed in 3D meshes with the use of the MUSIC software (inHEART, Bordeuax, France) and integrated within the EP lab environment to assist catheter ablation procedures. The MUSIC software is a proprietary software developed by cardiac electrophysiology and radiology researchers at the University of Bordeuax, France, that allows high-resolution recostruction of CT and MRI cardiac imaging for integration into electroanatomic maps in ablation procedures2,3.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:            

  • Male or female adults (≥ 18 years old).
  • Frequent premature ventricular complexes or documented episode(s) of sustained VT, or evidence of appropriate ICD therapy in patients already implanted with ICDs.
  • Structural heart disease, defined as impairment of left ventricular ejection fraction on echocardiography or MRI and/or presence of structural abnormality on imaging (myocardial late gadolinium enhancement on MRI, myocardial wall thinning, hypodensity or calcification on MDCT), and/or borderline, possible or definite diagnosis of arrhythmogenic right ventricular cardiomyopathy according to modified Task Force criteria.

Exclusion Criteria: 

  • Contraindications to VT/PVC catheter ablation:
    • Current intra-cardiac thrombus;
    • Unstable angina and other acute or reversible cause;
    • Current or anticipated participation in any other clinical trial of a drug, device or biologic.
  • Unwillingness to undergo CT and/or MRI imaging.

Eligibility last updated 1/21/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Konstantinos Siontis, M.D.

Open for enrollment

Contact information:

Halley Davison B.S.

(507) 422-6246

More information


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