18F-DOPA PET in Sarcoma Patients


About this study

The purpose of this study is to identify early response biomarkers from biological or functional imaging to better align with clinical trial endpoints and minimize sarcoma patient toxicities.



Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria - Pre Eligibility:

  • Age ≥ 18 years.
  • Histological confirmation of newly diagnosed sarcoma, or recurrent sarcoma ≥ 1 year post-treatment.
  • Tumors > 1 cm in diameter in largest dimension.
  • Operable sarcoma, planning to receive surgery or surgery with adjuvant RT at Mayo Clinic Florida.  Systemic therapy is allowed during radiotherapy.
  • Provide informed written consent.
  • Willingness to participate in mandatory imaging studies at Mayo Clinic Florida.

Exclusion Criteria - Post Eligibility:           

  • Individuals < 18 years.
  • 18F-DOPA PET uptake deemed as unacceptable for quantitative assessment.
  • Unable to undergo an 18F-DOPA PET/MRI scan due to standard MRI restrictions, such as for those with certain implanted devices, those who cannot fit inside the bore, or those with severe claustrophobia.
  • Any of the following:
    • Pregnant women;
    • Nursing women;
    • Men or women of childbearing potential who are unwilling to employ adequate contraception.

Eligibility last updated 9/2/21. Questions regarding updates should be directed to the study team contact.



Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Deanna Pafundi, Ph.D.

Open for enrollment

Contact information:

Cancer Center Clinical Trials Referral Office


More information


Publications are currently not available

Additional contact information

Cancer-related trials contact form

Phone: 855-776-0015 (toll-free)

International patient clinical studies questions