Pilot Study to Quantify Insulin Synthesis and Secretion In Vivo


About this study

The purpose of this study evaluates a subset of people with isolated Impaired Fasting Glucose with Normal Glucose Tolerance (i.e., IFG/NGT) believed to have normal β-cell function in response to a glucose challenge, suggesting that – at least in this subset of prediabetes – fasting glucose is regulated independently of glucose in the postprandial period. To some extent this is borne out by genetic association studies which have identified loci that affect fasting glucose but not glucose tolerance and vice-versa.


Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Previously participated in a prior study and expressed willingness to be recontacted or who respond to intramural and extramural adverts.
  • We propose three groups: 10 individuals who have NFG/NGT, 10 individuals with prediabetes (IGT) and 10 individuals with type 2 diabetes (T2DM).

Exclusion Criteria:

  • Medications that can affect glucose metabolism (to be determined by PI) or in the case of participants with T2DM taking pioglitazone.
  • For female subjects: positive pregnancy test.
  • Any active systemic illness.
  • Upper gastrointestinal surgery.

Eligibility last updated 8/20/21. Questions regarding updates should be directed to the study team contact.



Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Adrian Vella, M.D.

Open for enrollment

Contact information:

Jeanette Laugen

(507) 255-8110


More information


Publications are currently not available