A Study to Analyze Rhythm Control and Potential Early Surgery for Tricuspid Regurgitation


About this study

The purpose of this study is to determine the efficacy of a strategy of rhythm control to treat severe TR due to AF, followed by early surgery in non-responders to rhythm contron and to determine baseline clinical and hemodynamic predictors of symptom benefit following effective TR reduction. 


Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age ≥ 18 years.
  • Moderate-severe to severe TR due to atrial enlargement.
  • Ambulatory (not wheelchair/scooter dependent).
  • Ejection fraction > 40%.

Exclusion Criteria:

  • Systolic pulmonary artery pressure > 70 mmHg. with a fixed pulmonary vascular resistance > 7 Wood units by catheterization.
  • Ejection fraction < 40%.
  • Obstructive hypertrophic cardiomyopathy.
  • Constrictive pericarditis or tamponade.
  • Active myocarditis.
  • Complex congenital heart disease.
  • Other valve disease requiring surgical intervention.
  • Terminal illness (other than HF) with expected survival of less than 1 year.
  • Pregnancy or breastfeeding mothers.

Eligibility last updated 4/28/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Yogesh Reddy, M.B.B.S.

Open for enrollment

Contact information:

Peter Mathiason

(507) 255-0473


More information


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