Inclusion Criteria - All Subjects:

• Ability to understand and provide written informed consent.
• Age ≥ 50 years.
• Current or former smoker.
• ≥ 20 pack-years (pack years = number of packs per day X number of years smoked).

Inclusion Group 1 - High Risk Patients that meet criteria 5 and 6 below:

• Prior thoracic imaging (computed tomography (CT)) within 12 months of enrollment OR Planned thoracic imaging (CT) as part of standard of care within 6 weeks of enrollment AND
• Meet one of the criteria below:
  • No suspected or confirmed lung cancer diagnosis as defined by:
  • No clinical and/or radiological findings that indicate suspicion of lung cancer diagnosis (i.e., no lung nodules, < 6mm lung nodules, or ≥ 6mm lung nodules with no change from prior CT scan); OR
  • Suspected of lung cancer as defined by:
  • Radiological finding and/or clinical evaluation that indicates suspicion of lung cancer diagnosis (i.e., suspicious lung nodule(s) ≥ 6mm or Lung-RADS 3/4 for first-time CT scan patients and newly suspicious lung nodule(s) ≥ 6mm or Lung-RADS 3/4 identified within 6 months prior to enrollment for follow-up and surveillance CT scan patients). Subjects must have not received therapy prior to blood collection; OR
  • Confirmed, untreated lung cancer as defined by:
  • Pathologic diagnosis of lung cancer with no prior systemic therapy, definitive therapy, radiation, or surgical resection for any lesion.

Inclusion Group 2 - High Risk Patients with cancer other than lung cancer that meet the following criteria:

• Pathologic confirmed, solid-tumor cancer diagnosis, that is not lung cancer or nonmelanoma skin cancer, with no prior systemic therapy, definitive therapy, radiation, or surgical resection.

Exclusion Criteria - All Subjects:

• History of previous cancer or therapy for cancer within the year prior to enrollment.
• Any history of hematologic malignancies or myelodysplasia.
• Any history of organ tissue transplantation.
• Any history of blood product transfusion within prior month.
• Current pregnancy.
• Any condition that in the opinion of the Investigator should preclude the subject’s participation in the study.