A Study to Compare Marrow Venting Procedure Versus PRP


About this study

The primary objective of this study is to compare post-operative patient reported outcome measures of Bone Marrow Venting Procedure (BMVP) versus Platelet Rich Plasma (PRP) augmented meniscal repair.

The secondary objective is to compare outcomes of BMVP versus PRP as related to meniscal repair failure.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age 16-55 years old.
  • Medial, lateral, vertical longitutdinal, oblique, or radial meniscal tear.
  • Complex tears may be included (investigator discetion) if the patient has one of the tear patterns listed in incluse as the predominant finding.
  • No other concomitant procedures unless (one of the following):
    • Chondroplasty;
    • Synovectomy;
    • Loose body removal;
    • “Contralateral” menisectomy (i.e., medial meniscus repair with a lateral menisectomy or lateral meniscus repair with a medial menisectomy) would be permitted for inclusion;
    • Any other procedure that does not include drilling, requires prior approval of the study sponsor for each procedure.

Exclusion Criteria:

  • Patients requiring cartilage restorative or repair procedures (i.e., OCD fixation, micro-fracture repair, or others).
  • Patients with meniscus root tears.
  • Patients undergoing repair for horizontal cleavage tears.
  • Kellgren-Lawrence scale > 2.
  • Patients undergoing lateral release.
  • Ipsilateral chondral lesion with Outerbridge classification of 3-4.
  • Use of prednisone or other steroids, any immunosuppressant, or chemotherapy 1-week before surgery or expected use within six weeks after surgery.
  • Cortisone use within the six weeks prior to surgery.
  • Utilizing worker’s compensation at the time of screening.
  • Any previous ligament surgery on the index limb. Any previous meniscal surgery on the index meniscus.
  • Concomitant ligamentous insufficiency.
  • Inflammatory rheumatic disease or other rheumatic disease.
  • Immune compromised patients (hepatitis, HIV, etc.).
  • Any nicotine based products within the three months prior to surgery (including cigarettes, cigars, vaping, nicotaine patch, etc.).
  • History of distal femur, proximal tibia, or patellar fracture that was treated operatively.
  • Non English-speaking patients.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Michael Stuart, M.D.

Closed-enrolling by invitation

What is this? (?)
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Ciara Terry

(507) 538-3562


More information


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