Regulation of Muscle Protein Phenotype in Humans with Obesity
Overview
Tab Title Description
Study type
InterventionalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
NCT ID: NCT04700800
About this study
The purpose of this study is to determine the turnover rate of motor protein isoforms (myosin heavy chain, MHC) and overall muscle protein in skeletal muscle of subjects with obesity and lean controls in the basal state, and to determine stimulation of the turnover rate of motor protein (MHC isoforms) in skeletal muscle of subjects with obesity and lean controls by plasma amino acids and with and without prior exercise.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
- ability to sign informed consent form
- body mass index (BMI), 18-26 kg/m2 (lean subjects), 32-50 kg/m2 (subjects with
obesity)
Exclusion Criteria:
- prescription or over-the-counter medication
- supplements known to affect protein metabolism (i.e., amino acids, protein, omega-3
fatty acids)
- diabetes
- acute illness
- liver disease
- uncontrolled metabolic disease, including renal disease
- heart disease related to atrial fibrillation, history of syncope, limiting or unstable
angina, congestive heart failure or ECG documented abnormalities
- low hemoglobin or hematocrit
- use of anabolic steroids or corticosteroids (within 3 months)
- not classified as inactive/sedentary based on the Stanford Brief Activity Survey and
accelerometry data
- participation in a weight-loss regimen
- extreme dietary practices (i.e., vegan, vegetarian)
- smoking
- pregnancy
- gastro-intestinal surgery
- any other condition or event considered exclusionary by the PI and the study
physician.
Note: Other protocol defined Inclusion/Exclusion Criteria may apply.
Eligibility last updated 4/8/2024. Questions regarding updates should be directed to the study team contact.
More information
Publications
Publications are currently not available