Inclusion Criteria: -Female -Age 18 years or older -Patients undergoing elective breast conservation surgery for the treatment of Stage 0-III invasive ductal and/or ductal carcinoma in situ -May include subjects treated with neo-adjuvant therapy (endocrine and/or chemotherapeutic), but not required for study inclusion -Ability to understand and the willingness to sign a written informed consent document Exclusion Criteria: -Male -Metastatic cancer (Stage IV) -Lobular carcinoma as primary diagnosis -Previous ipsilateral breast surgery for benign or malignant disease (this includes implants and breast augmentation) -Subjects with multi-centric disease (histologically diagnosed cancer in two different quadrants of the breast), unless resected in a single specimen -Subjects with bilateral disease (diagnosed cancer in both breasts) -Participating in any other investigational margin assessment study which can influence collection of valid data under this study -Use of cryo-assisted localization -Currently lactating -Current pregnancy -Subjects for whom the specimen margins have been destroyed, damaged, or are otherwise not intact prior to imaging (device arm only) imaging