Service Line TransPerc


About this study

The purpose of this study is to compare transcutaneous electrical spinal stimulation and epidural electrical spinal stimulation.  Relationships between stimulation input and electrophysiological output will be recorded, and changes in motor, sensory, and functional outcomes during and after stimulation will be assessed.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:                                        

  • Spinal cord injury due to trauma located at or above the tenth thoracic vertebrae (T10).
  • American Spinal Injury Association grading scale of A-D (2 from each) below the level of SCI.
  • Intact spinal reflexes below the level of SCI.
  • At least 1-year post-SCI.
  • At least 22 years of age.
  • Willing to use medically acceptable methods of contraception, if female and of child-bearing potential.
  • Completed vaccination series for SARS-CoV-2.

Exclusion Criteria:

  • Currently a prison inmate, or awaiting trial, related to criminal activity.
  • Pregnancy at the time of enrollment.
  • DEXA t score ≤ 3.5 at spine and femur head.
  • History of chronic and/or treatment resistant urinary tract infection.
  • Unhealed decubitus ulcer.
  • Unhealed skeletal fracture.
  • Untreated clinical diagnosis of depression.
  • More than 30 mg of anti-spasticity medication per day.
  • Undergoing, or planning to undergo, diathermy treatment
  • Active participation in another interventional clinical trial.
  • Presence of conditions or disorders which require MRI monitoring.
  • A history of coagulopathy or other significant cardiac or medical risk factors for surgery.
  • Current use of a ventilator.
  • Clinically diagnosed cardiopulmonary complications such as chronic obstructive pulmonary disease, cardiac failure, or heart arrhythmia that contraindicate changes in body position such as supine-to-sit-to-stand activities, prolonged standing, or stepping.
  • Mass > 113 kg (250 pounds).
  • History of frequent hypotension characterized by light headedness, or loss of consciousness.
  • History of frequent hypertension characterized by headache, or bradycardia.
  • History of frequent, severe, autonomic dysreflexia.
  • Any illness or condition which, based on the research team’s assessment, will compromise with the patient’s ability to comply with the protocol, patient safety, or the validity of the data collected during this study.

Eligibility last updated 1/6/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Kristin Zhao, Ph.D.

Open for enrollment

Contact information:

Tyson Scrabeck CCRP

(507) 538-1016

More information


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