White Matter Hyperintensities in Migraine: A Multi-modal Imaging Project to Classify Disease Pathology

Overview

About this study

The purpose of this research is to better understand brain white matter hyperintensities (WMH) in women with migraine. We will accomplish this by comparing brain imaging and clinical assessments of women with migraine, small vessel ischemic (SVI) disease, and multiple sclerosis (MS).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria - Migraine (N=20):

  • Female only.
  • Ages 20-45 years.
  • Presence of WMH on MRI.

Exclusion Criteria:

  • History of SVI and/or history of MS or other neurological disease other than migraine.
  • History of cancer or organ transplantation.
  • Contraindication to MRI.
  • Pregnancy.
  • History of abnormal brain MRI other than WMH.
  • Subjects not willing to comply with the study procedures will be removed from the study.

Inclusion Criteria - SVI disease (n=10):

  • Female only
  • Ages > 60 years.
  • Presence of WMH on MRI.

Exclusion Criteria:

  • History of migraine and/or history of MS or other neurological disease other than SVI.
  • History of cancer or organ transplantation.
  • Hhistory of abnormal brain MRI other than WMH.
  • Pregnancy.
  • History of abnormal brain MRI other than WMH.
  • Subjects not willing to comply with the study procedures will be removed from the study.

Inclusion Criteria - MS (n=10):

  • Female only.
  • Ages 20-45.
  • Presence of WMH on MRI.

Exclusion Criteria:

  • History of migraine and/or history of SVI or other neurological disease other than MS.
  • History of cancer or organ transplantation.
  • History of abnormal brain MRI other than WMH.
  • Pregnancy.
  • History of abnormal brain MRI other than WMH.
  • Subjects not willing to comply with the study procedures will be removed from the study.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Catherine Chong, Ph.D.

Open for enrollment

Contact information:

Nicole Williams B.S.

(480) 342-3757

Williams.Nicole1@mayo.edu

More information

Publications

Publications are currently not available