A Study to Measure Hemolysis Markers in Subjects with Warm Autoimmune Hemolytic Anemia

Overview

About this study

The purpose of this study is to measure and characterize markers of hemolysis (including but not limited to lactate dehydrogenase, indirect bilirubin, haptoglobin, and reticulocyte count), complement activation, and direct antiglobulin test (DAT), from subjects with Warm Autoimmune Hemolytic Anemia (wAIHA). 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Male or female, ≥ 18 years of age at the time of informed consent.
  • History of hemolysis that is not adequately controlled, as confirmed by enrolling investigator.
  • Positive direct antiglobulin test (DAT) ≥ 1+ for C3d and IgG.
  • Hgb level < 10.0 g /dL(pre-transfusion) with no alternative explanation for anemia apart from wAIHA.
  • Evidence of active hemolysis based on at least one of the following:
    • LDH above the ULN;
    • Indirect bilirubin above the ULN;
    • Haptoglobin below the LLN.
  • Willing and able to give informed consent.

Exclusion Criteria:

  • < 18 years of age.

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Ronald Go, M.D.

Closed-enrolling by invitation

What is this? (?)
"Close"
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Vishakantha Murthy Ph.D., M.B.A., CCRP

(507) 255-8112

Murthy.Vishakantha@mayo.edu

More information

Publications

Publications are currently not available