Nitrates and IL-8 in Barrett's Esophagus
Tab Title Description
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
- Rochester, Minnesota: 20-004618
NCT ID: NCT04642690
Sponsor Protocol Number: 20-004618
About this study
The purpose of this study is to determine serum, saliva, and tissue levels of nitrates in patients with normal squamous epithelium, erosive esophagitis, non-dysplastic BE (NDBE), and BE with high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC); to compare serum and tissue levels of IL-8 with varying levels of BE dysplasia and EAC; and to determine whether there is an association between nitrate levels and IL-8.
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
- Patients undergoing a clinicallly-indicated Esophagogastroduoedoscopy (EGD).
- Comorbid inflammatory medical condition.
- Use of antiinflammatory (aspirin and NSAIDs) or immunosuppressants over the past 1 week.
- Use of nitrate containing medication in the past 1 week.
- Consumption of nitrate rich foods in preceding 24 hours.
- Known allergy to meat or nitrates
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
|Mayo Clinic Location
Mayo Clinic principal investigator
David Katzka, M.D.
Open for enrollment
Justin Patri B.S.
Publications are currently not available