A Study to Evaluate Neuroimaging of Men with Migraine


About this study

The purpose of this study is to find sex-based differences in migraine-related functional connectivity. To achieve this, men with migraine will be compared to men healthy controls and women with migraine will be compared to women healthy controls.

Men and women with migraine will then be compared, using region-pairs that differed in the single-sex comparisons.  Identification of migraine-related, sex-specific, functional imaging aberrations will provide insights into sex-specific migraine pathophysiology and will inform future imaging studies

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adults, 18-70 years of age.
  • Male subjects with history of migraine and healthy male control subjects.
  • Migraine subjects will be diagnosed using the ICHD-3 diagnostic criteria for migraine.

Exclusion Criteria:

  • History of neurological disorder other than migraine.
  • Prior history of gross anatomical change on imaging.
  • Contraindications to MRI including, but not limited to, severe claustrophobia and/or presence of ferrous materials in the body.
  • Additionally, exclusion criteria for healthy controls include a history of migraine or other headaches.
  • Tension-type headaches on three or fewer days per month is allowed for healthy control subjects.

Eligibility last updated 1/6/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Gina Dumkrieger, Ph.D.

Open for enrollment

Contact information:

Gina Dumkrieger Ph.D.

(480) 301-8100

More information


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