Inclusion Criteria:

• Subjects and/or their legal guardian must provide written informed consent, in accordance with federal and/or local laws, before any study procedures occur. In addition, if applicable, a minor child must provide written informed assent in accordance with federal and/or local laws as well as in compliance with the recommendations of the approving Institutional Review Board (IRB), before any study procedures occur.
• Male or female, ≥ 2 years of age at the Screening visit (when consent/assent for study participation is given).
• Clinical diagnosis of RDEB with confirmation of COL7A1 genetic mutation.
• At least two eligible persistent non-healing or recurrent wounds identified at Day 1 (Visit 2):
  • Each wound must have an approximate minimum area of 10 cm2 and a maximum of 50 cm^2;
  • Wound site was monitored for at least 12 weeks prior to Day 1 (Visit 2) and wound is open (unhealed);
  •  The following wounds are excluded:
    • Wounds on a mucous membrane, the face, hands, feet, or fully across joints;
    • Wounds with active infection or evidence of active infection;
    • Wounds that have been previously treated with a gene therapy intervention.
• Female subjects of childbearing potential and post-pubertal male subjects engaging in sexual activity that could lead to pregnancy who agree to using at least one of the following adequate birth control regimens while in the study and for 6 months after last dose of FCX-007 is administered:
  • Male partner with vasectomy; OR
  • Male condom AND partner use of one of the contraceptive options below:
    • Spermicide;
    • Intrauterine device or intrauterine system;
    • Oral contraceptive, either combined or progestogen alone;
    • Contraceptive subdermal implant (e.g., Norplant®);
    • Injectable progestogen (e.g., Depo-Provera®);
    • Contraceptive vaginal ring (e.g., NuvaRing®);
    • Transdermal contraceptive patches (e.g., Ortho Evra®).
• Subjects of childbearing potential who are abstinent are eligible, but they must agree to use one of the birth control regimens listed above if they begin engaging in sexual activity that could lead to pregnancy during the study.
• Periodic abstinence; e.g., calendar, ovulation, sympto-thermal, post-ovulation methods and withdrawal are not acceptable methods of contraception.
  • NOTE: Subjects using an acceptable hormonal based contraceptive must have been on a stable dose for at least 3 months before Day 1 (Visit 2) and be willing to continue stable birth control methods throughout the study.
• Non-childbearing potential females are defined as females who are premenarchal, or postmenopausal (12 months with no menstrual period without an alternative medical cause), or who have undergone a hysterectomy, bilateral tubal ligation, bilateral oophorectomy (removal of the ovaries), or hysteroscopic sterilization. Documented verbal history from the subject is acceptable.
• Subjects and/or their legal guardian, if applicable, who are, in the opinion of the Investigator, able to understand the study, cooperate with the study procedures and are willing to return to the clinic for all required follow-up visits.

Exclusion Criteria: