A Study to Evaluate Exercise Capacity and Positive Airway Pressure Impact on Sleep Apnea in Heart Failure

Overview

About this study

The purpose of this study is to determine the prevalence of Obstructive Sleep Apnea (OSA) in HFpEF, and its clinical and hemodynamic correlates, and to determine the impact of intervention with CPAP therapy on exercise capacity and quality of life in HFpEF patients with OSA.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age ≥ 18 years.
  • Diagnosis of HFpEF by catheterization with resting PCWP > 15 mmHg or exercise PCWP > 25 mmHg.
  • Ambulatory (not wheelchair/scooter dependent).
  • If no known diagnosis of OSA, must not be pacemaker dependent with with either atrial pacing or VVI without sinus rhythm.
  • If no known diagnosis of OSA, must be able to temporarily hold nitrates or alpha channel blockers for home WatchPAT testing.
  • Access to smartphone for WatchPAT data transfer.

Exclusion Criteria:

  • Ejection fraction < 40%.
  • Obstructive hypertrophic cardiomyopathy.
  • Constrictive pericarditis or tamponade.
  • Active myocarditis.
  • Complex congenital heart disease.
  • Other valve disease requiring surgical intervention.
  • Terminal illness (other than HF) with expected survival of less than 1 year.
  • Enrollment or planned enrollment in another therapeutic clinical trial in next 3 months.
  • Inability to comply with planned study procedures.
  • Pregnancy or breastfeeding mothers.

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Yogesh Reddy, M.B.B.S.

Contact us for the latest status

Contact information:

Andrew Moscho B.S.

(507) 255-7072

Moscho.Andrew@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

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