A Study to Evaluate TAK-018 for Prevention of the Recurrence of Postoperative Crohn's Disease (CD)

Overview

About this study

The purpose of this study is to evaluate the effectiveness of TAK-018 in reducing endoscopic recurrence of intestinal inflammation in postoperative participants with CD after a planned laparoscopic ileocecal resection with primary anastomosis.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Must have a documented diagnosis of CD confirmed by endoscopic biopsy before resection or by tissue obtained at resection.
  • Planned to undergo a laparoscopic ileocecal resection with primary anastomosis within 72 hours before randomization Day 1. Confirmation that no active disease has been left behind after resection will be based on surgeon's documentation in the operative report.
  • With postoperative discontinuation of all concomitant medications specifically related to the treatment of CD. This includes anti-tumor necrosis factor-alpha (TNF-α) and anti-integrin therapy, anti- interleukin (IL) 12/23, thiopurines and other immunomodulators, steroids, 5-minosalicylates, and prophylactic use of antibiotics for the prevention of postoperative recurrence such as metronidazole.
  • Has resumed oral intake and is capable of swallowing tablets after surgery.

Exclusion Criteria:

  • Has active perianal CD.
  • Has had > 3 previous surgical procedures for CD.
  • Has macroscopically active CD that was not resected at the time of surgery as documented in the surgeon's operative report.
  • With small bowel resection that exceeds 100 centimeter (cm) or a participant who is considered at risk of short bowel syndrome by the surgeon or investigator.
  • Has active or latent tuberculosis, regardless of treatment history, as evidenced by any of the following:
    • history of tuberculosis; OR
    • positive QuantiFERON test or 2 successive indeterminate QuantiFERON tests; OR
    • a tuberculin skin test reaction ≥ 10 millimeter (mm) (≥ 5 mm in participants receiving the equivalent of >15 milligram per day (mg/day) prednisone).
  • Has chronic hepatitis B (hepatitis B surface antigen positive, or positive for both hepatitis B surface antibody and hepatitis B core antibody but negative for hepatitis B surface antigen) or hepatitis C infection (evident by viral replication by polymerase chain reaction) within 30 days of randomization.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Francis Farraye, M.D., M.S.

Open for enrollment

Contact information:

Rachel Pung Page

White.Rachel2@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available