Remote Self-training Program for Patients with Postural Orthostatic Tachycardia Syndrome (POTS)


About this study

The study aims to evaluate if a hybrid semi-supervised remote monitoring three month strength and aerobic exercise training program can be as efficacious as in-person exercise training has previously demonstrated. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Must be 18 years old or older.
  • Meet diagnosis criteria for POTS = a heart rate increase of ≥ 30bpm with supine to 10 minutes of standing or head-up tilt or heart rate exceeding 120 ppm after 10 minutes of standing or tilt without evidence of orthostaticth POTS ≥ 6 months prior to participation in the study (chronic).
  • Those in ET group must be on stable medications for at least 1 month and medication must remain consistent for duration of study participation. For those in the SC group, a change in medication will be allowed within the first month following baseline testing, but then must remain consistent until 3-month testing time point.
  • Ehlers-Danlos Syndrome (EDS) patients will be included, but will target equal randomization between treatment groups.

Exclusion Criteria:

  • Female subjects must not be pregnant or trying to become pregnant during duration of study participation
  • Individual is not eligible if they are currently exercising, cut off >30 minutes of structured exercise/physical activity per week. (assessed by Global Physical Activity Questionnaire)

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Courtney Wheatley-Guy, Ph.D.

Closed for enrollment

More information


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Additional contact information

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Phone: 800-664-4542 (toll-free)

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