Exercise-stimulated Muscle Glucose Uptake in Upper Body Obesity


About this study

The purpose of this study is to provide the first integrated examination of the interaction between muscle insulin action and exercise-stimulated muscle glucose uptake in obesity from the whole body to the cellular/molecular level.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

Insulin Sensitive Group

  • Sedentary, normal weight, premenopausal women.
  • Sedentary, age-matched normal weight men.

Insulin Resistant Group

  • Premenopausal, non-diabetic UBO (upper body obesity) women.
  • Age-matched, non-diabetic men with UBO.
  • Weight stable for two (2) months prior to study.
  • Willing to provide written, informed consent.

Exclusion Criteria:

  • Age < 18 or > 55 years (premenopausal women and age-matched men).
  • Use antidiabetic medications.
  • For female subjects: positive pregnancy test at the time of enrollment or study
  • History of bariatric surgery.
  • Active systemic illness or malignancy.
  • Symptomatic macrovascular or microvascular disease.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Michael Jensen, M.D.

Open for enrollment

Contact information:

Sarah Wolhart R.N.

(507) 255-6940


More information


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