Ventricular Arrhythmia Increases Sympathetic Activity Determined By A Skin Nerve Recording


About this study

The purpose of this study is to utilize neuECG, a new method to directly and non-invasively record skin sympathetic nerve activity (SKNA) and electrocardiogram (ECG), to non-invasively assess the effects radiofrequency catheter ablation (RFCA) on SKNA in patients at high risk for life-threatening ventricular arrhythmias (VA).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients who have non-sustained or sustained VA (VA ≥ 30s or receiving appropriate ICD therapies).
  • The causes of VA are associated with structural heart diseases including ischemic or nonischemic cardiomyopathy (idiopathic cardiomyopathy, hypertrophic cardiomyopathy, cardiac sarcoidosis or amyloidosis, and arrhythmogentic right ventricular dysplasia) and nonstructural heart diseases.
  • Subjects 18 years of age and older.

Exclusion Criteria:


  • Female patients who are pregnant or of childbearing potential and not on a reliable form of birth control.
  • Individuals allergic to skin patch electrodes.
  • Vulnerable populations (fetuses, neonates, pregnant women, prisoners, institutionalized individuals).

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Yongmei Cha, M.D.

Open for enrollment

Contact information:

Andrew Moscho B.S.

(507) 255-0774

More information


Publications are currently not available