Noninvasive Evaluation of Renal Allograft Fibrosis by MRI


About this study

The purpose of this study is to validate an MRI method to detect renal fibrosis in patients after kidney transplantation (KT).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age 18-80 years.
  • Recipient of living donor kidney transplantation 4 or 7 years earlier.
  • Competent and able to provide written informed consent.
  • Ability to comply with protocol.

Exclusion Criteria:

  • Patients have clinically significant medical conditions within the prior 6 months before; e.g., myocardial infarction, congestive heart failure, stroke, that would, in the opinion of the investigators, compromise the safety of the patient.
  • Severe chronic liver, heart, or lung disease.
  • Undergoing acute rejection.
  • Contra-indication to biopsy; bleeding disorders.
  • Chronic infection.
  • Any active malignancy and undergoing therapy.
  • Kidney or ureteric stone.
  • Unable to give valid informed consent.
  • Known pregnancy or intent to conceive during the study period.
  • Pacemaker, implantable defibrillator, magnetically active metal fragments, claustrophobia or other contraindication to MRI.
  • Federal medical center inmates.
  • Latex allergy.


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Lilach Lerman, M.D., Ph.D.

Open for enrollment

Contact information:

Beverly Tietje C.S.T.

(507) 255-0401

More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

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