A Study to Compare Neuromuscular Monitoring of The Thumb and Great Toe Muscles with Electromyography


About this study

The purpose of this study is to assess the onset of neuromuscular blockade and recovery profiles of aminosteroidal neuromuscular blocking agents (NMBAs) after sugammadex at the flexor hallucis brevis (great toe) and adductor pollicis (thumb) muscles.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age ≥ 18 years old.
  • Patients willing to participate and provide an informed consent.
  • Patients undergoing an elective surgical procedure that requires use of non-depolarizing.
  • NMBA agents administered intraoperatively.
  • Patients with planned administration of sugammadex as a neuromuscular blocking reversal agent.

Exclusion Criteria:

  • Patients with disorders, such as stroke, carpal tunnel syndrome, broken wrist with nerve damage, Dupuytren contracture, or any similar wrist injury.
  • Patients with systemic neuromuscular diseases such as myasthenia gravis.
  • Patients with significant organ dysfunction that can significantly affect pharmacokinetics of neuromuscular blocking and reversal agents; i.e., severe renal impairment or end-stage liver disease.
  • Patients having surgery that would involve prepping the arm or leg into the sterile field.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Johnathan Renew, M.D.

Open for enrollment

Contact information:

Johnathan Renew M.D.

(904) 956-3328


More information


Publications are currently not available

Study Results Summary

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Supplemental Study Information

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