A Study Assessing DNA Markers For The Detection Of Pancreatic Cancer And Precancer
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Scottsdale/Phoenix, Arizona: 14-009169
- Jacksonville, Florida: 14-009169
- Rochester, Minnesota: 14-009169
Sponsor Protocol Number: 14-009169
About this study
The purpose of this study is to assess DNA markers in pancreatic juice and stool for the detection of pancreatic cancer and precancer.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria
- Cases
- Pancreatic cancer (adenocarcinoma)
- Pancreatic precancer (includes IPMN (Branch-IPMN, Main duct-IPMN, Mixed-IPMN), Mucinous cystic neoplasms, and Serous cystadenomas)
- If surgery is not done, a chart review may be done for up to 5 years to follow the cyst over time.
- Controls
- Normal pancreas on EUS (or absence of features suggesting neoplasia)
- No personal history of pancreatic neoplasia or of GI cancer at any level
- Includes
- Asymptomatic patients undergoing surveillance or diagnostic examination
- Ideal group would be those undergoing EUS for evaluation of non-pancreatic lesions unlikely to shed luminal cells (e.g. small submucosal gastric lesions)
- Patients with chronic dyspepsia (> 2 years), iron deficiency, or anemia
- Patients with family history of pancreatic cancer
- Patients with recurrent idiopathic pancreatitis or chronic pancreatitis found to have no lesions suspicious for pancreatic cancer on imaging
Exclusion Criteria
- A positive pregnancy test
- A pregnancy test will be obtained in premenopausal women agreeing to participate,and must be shown to be negative prior to endoscopy and secretin injection
- Organ transplant
- Pancreatic cancer is a recurrence
- Received a chemotherapy class drug in past 6 months or are actively receiving one
- Therapeutic radiation to esophagus or thorax/chest
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Scottsdale/Phoenix, Ariz.
Mayo Clinic principal investigator |
Closed for enrollment |
|
Jacksonville, Fla.
Mayo Clinic principal investigator Massimo Raimondo, M.D. |
Closed for enrollment |
|
Rochester, Minn.
Mayo Clinic principal investigator |
Closed for enrollment |
|
More information
Publications
Publications are currently not available