Inclusion Criteria:

• Provision of signed and dated informed consent form 
• Started willingness to comply with all study procedures and availability for the duration of the study 
• Male or female, age ≥ 12 years 
• No change in asthma medications for the past 2 months and use of medium or high dose inhaled corticosteroids (ICS) (defined by Table 1A) + an additional asthma controller/biologic (defined in Tables 1B and 1C). Participants entered into the run-in on medium dose ICS will be switched to high dose ICS. They must meet all entry criteria at the time of randomization including the criteria for uncontrolled asthma as assessed by symptoms during the two weeks prior to the randomization. 
• Baseline poor or uncontrolled asthma, defined as meeting at least one of the following: 1. FEV1 <80% predicted (for adults ≥18) or FEV1<90% (pediatric participants <18) AND with 12% bronchodilator reversibility 2. Poor symptom control - Asthma Control Questionnaire ( ACQ-6) Score ≥1.5.   

Exclusion Criteria:

• Current participation in an interventional trial (e.g. drugs, diets, etc.) 
• Enrollment in a clinical trial where the study medication was administered within the past 60 days or within 5 half-lives (whichever is greater) 
• Physician diagnosis of other chronic pulmonary disorders associated with asthma-like symptoms, including, but not limited to, cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, severe scoliosis or chest wall deformities that affect lung function, or congenital disorders of the lungs or airways 
• Receiving one or more immune-modulating therapies for diseases other than asthma 
• Receiving methotrexate, mycophenolate (CellCept®), or azathioprine (Imuran®) 
• Receiving aero allergen immunotherapy and not on at least 3 months of maintenance allergen immunotherapy 
• History of smoking 1. If <30 years old: Smoked for ≥5 pack-years* -Can still be enrolled if <30, smoked <5 5 pack years and none in past year, and normal (negative) urine cotinine
• 2. If 30-39 years old: Smoked for ≥10 pack years -Can still be enrolled if ≥30, smoked <10 pack years and none in past year, provided participant demonstrates a normal (negative) urine cotinine
• 3. If ≥40 years old: Smoked ≥15 pack years -Can still be enrolled if ≥40 years old, smoked <15 pack years and none in the last year, provided participant demonstrates normal (negative) urine cotinine. Patients with a smoking history of ≥10 to <15 pack years will also need to demonstrate a normal Diffusing Capacity for Carbon Monoxide (DLCO) (>70% predicted) * Smoking equivalent pack years. One pack of cigarettes a day for 1 year is equivalent to: 1. 1 cigar or pipe per day for 1 year 2. Smoked hookah or shisha =1 session per day for 1 year 
• Vaped e-cigarettes =0.5 mLs e-liquid per day for 1 year, or =1 cartridge/tank/pod per day for 1 year 
• 1 use of marijuana per day for 1 year 
• Active use of any inhalant >1 time per month in the past year 
• Active smoking of conventional tobacco, inhaling of marijuana or other drugs, or vaping of e-cigarettes or vape pods >1 time per month in the past year. Any form of tobacco qualifies, such as: 1 cigarette, 1 hookah or shisha sessions, 1 cigar, 1 pipe, etc. Any electronic (e)-device included: e-cigarette e-cig, mod, vape pen, JUUL vaping device, e-cigar, e-hookah, e-pipe, vape pods, etc. Any form of inhaled marijuana, including smoking marijuana leaves or inhaling THC (tetrahydrocannabinol) via e-cigarette or device