Inclusion Criteria:

• Eastern Cooperative Oncology Group (ECOG) performance status ≤1 Individual cases of patients with ECOG 2 performance status, whose ECOG status is expected to improve as a consequence of effective therapy, may be discussed with the medical monitor for potential enrollment.
• Patients must have symptomatic myeloma at the time of study entry with myeloma-related organ damage or tissue dysfunction (such as hypercalcemia, renal insufficiency, bone lytic lesions, or anemia).
• Patients must have myeloma that is measurable by either serum or urine evaluation of the monoclonal component or by assay of serum free light chain (FLC).
• Measurable disease is defined as 1 or more of the following:
  • Serum M-protein ≥ 1 g/dL;
  • Urine M-protein ≥ 200 mg/24-hour; and/or
  • FLC assay with involved FLC level ≥10 mg/dL with an abnormal serum FLC ratio.
• A patient with Immunoglobulin A (IgA) myeloma but without measurable M-protein may be enrolled if quantitative IgA levels are elevated and can be followed longitudinally.
• A patient with non-secretory MM may be considered for enrollment after discussion with the sponsor that includes the feasibility of an individualized plan for response assessment
• Patients with MM who have exhausted all therapeutic options that are expected to provide meaningful clinical benefit, either through disease relapse, treatment refractory disease, or intolerance or refusal of the therapy, and including either:
  • Progression on or after at least 3 lines of therapy, or intolerance of therapy, including a proteasome inhibitor, an IMiD, and an anti-CD38 antibody; OR
  • Progression on or after an anti-CD38 antibody and have disease that is "double refractory" to a proteasome inhibitor and an IMiD, or intolerance of therapy. The anti-CD38 antibody may have been administered alone or in combination with another agent such as a proteasome inhibitor. Refractory disease is defined as lack of response or relapse within 60 days of last treatment.
• Adequate hematologic function as measured by:
  • Platelet count > 50 x 10^9/L. A patient may not have received a platelet transfusion within 7 days in order to meet this platelet eligibility requirement;
  • ANC > 1.0 x 10^9/L. A patient may not have received granulocyte colony stimulating factor (G-CSF) within 2 days in order to meet this absolute neutrophil count eligibility requirement;
  • Hemoglobin > 8.0 g/dL.
• Adequate hepatic function, defined as:
  • Total bilirubin ≤ 1.5 x ULN;
  • Transaminase (ALT, AST) ≤ 2.5 x ULN ;
  • Alkaline phosphatase ≤ 2.5 x ULN.
• Patients with Gilbert syndrome do not need to meet this total bilirubin requirement provided that the total bilirubin is unchanged from the baseline value.
• Serum creatinine clearance by Cockcroft-Gault >30 mL/min.
• A patient with a creatinine clearance by Cockcroft-Gault who does not meet eligibility criteria may be considered for enrollment if a measured creatinine clearance (based on 24-hour urine collection or other reliable method) is >30 mL/min.
• Life expectancy of at least 6 months.

Exclusion Criteria:

• Patients with known MM brain lesions or meningeal involvement with MM (suspected central nervous system (CNS) myeloma should be excluded by radiographic imaging and/or lumbar puncture, as appropriate).
• History of neurodegenerative condition or CNS movement disorder.
• Cardiac ejection fraction < 40% by echocardiogram or multi-gated acquisition scan (MUGA).
• Additional Exclusion Criteria may apply.