A Study to Assess the Effectiveness of Osimertinib Plus Savolitinib in Patients with Locally Advanced or Metastatic Non Small Cell Lung Cancer Who Have Progressed Following Osimertinib Treatment (SAVANNAH Study) Following Prior Osimertinib


About this study

The purpose of this study (the SAVANNAH study) is tol investigate the effectiveness of osimertinib in combination with savolitinib in patients with EGFRm+ and MET+, locally advanced or metastatic Non Small Cell Lung Cancer (NSCLC) who have progressed following treatment with osimertinib.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion criteria:

- Patients must be ≥18 years of age (≥20 years of age in Japan). All genders are

- Histologically or cytologically confirmed locally advanced or metastatic EGFRm+ NSCLC
harbouring an EGFR mutation known to be associated with EGFR TKI sensitivity and
permitted in the osimertinib national label (such as either exon 19 deletion and/or
L858R) which is not amenable to curative therapy.

- Documented radiologic disease progression on 1L osimertinib.

- MET amplification and/or overexpression (FISH10+ and/or IHC90+) as determined by FISH
(central) and IHC (central) testing on tumour sample collected following progression
on 1L osimertinib treatment.

- Available tumour sample for central MET FISH and IHC analysis or willingness to
collect additional sample for central testing which fulfils the following

Obtained following progression on previous osimertinib therapy;

obtained within 2 years of submission for MET analysis;

sufficient tissue to meet the minimum tissue requirement defined in the current Laboratory

- At least 1 lesion, not previously irradiated, not biopsied during the screening
period, that can be accurately measured at baseline as ≥10 mm in the longest diameter
(except lymph nodes which must have short axis ≥15 mm) with CT or MRI which is
suitable for accurate repeated measurements. If only 1 measurable lesion exists, it is
acceptable to be used as long as baseline tumour assessment scans are done at least 14
days after the screening tumour sample collection is performed.

- Prior lines of therapy in locally advanced/metastatic setting: Only prior 1L
osimertinib treatment in metastatic setting is permitted.

- Adequate haematological function defined as:

- Absolute neutrophil count ≥1500/?L

- Haemoglobin ≥9 g/dL (no transfusion in the past 2 weeks)

- Platelets ≥100,000/?L (no transfusion in the past 10 days)

- Adequate liver function

- ALT, AST ≤2.5 x ULN with TBL ≤ ULN OR

- TBL >ULN to ≤1.5x ULN with ALT and AST ≤ ULN

- Adequate renal function - defined as a serum creatinine <1.5 times the institutional
ULN OR a glomerular filtration rate ≥50 mL/min. Confirmation of creatinine clearance
is only required when creatinine is only required when creatinine is >1.5 times ULN.

- Adequate coagulation parameters: INR <1.5 and activated partial thromboplastin time
<1.5 x ULN unless patients are receiving therapeutic anti coagulation which affects
these parameters.

- Patients with known tumour thrombus or deep vein thrombosis are eligible if clinically
stable on low molecular weight heparin for ≥2 weeks. The use of direct oral
anticoagulants such as apixaban/rivaroxaban will be accepted as treatment for cancer
related thromboembolism treatment. The use of warfarin for oral anticoagulation is not

- ECOG/WHO performance status of 0 or 1 with no deterioration over the previous 2 weeks
and a minimum life expectancy of 12 weeks.

- Females must be using highly effective contraceptive measures, should not be breast
feeding and must have a negative pregnancy test if of childbearing potential, or must
have evidence of non-childbearing potential.

- Males with a female partner of childbearing potential should be willing to use barrier
contraception during the study and for 6 months following discontinuation of study

Exclusion Criteria:

- Unresolved toxicities from any prior therapy greater than CTCAE Grade 1 at the time of
starting study treatment with the exception of alopecia and Grade 2 prior platinum
therapy related neuropathy.

- As judged by the investigator, active gastrointestinal disease or other condition that
will interfere significantly with the absorption, distribution, metabolism, or
excretion of oral therapy (eg, ulcerative disease, uncontrolled nausea, vomiting,
diarrhoea Grade ≥2, malabsorption syndrome or previous significant bowel resection).

- Any of the following cardiac diseases currently or within the last 6 months:

Unstable angina pectoris

Congestive heart failure (New York Heart Association [NYHA] ≥Grade 2)

Acute myocardial infarction

Stroke or transient ischemic attack

Uncontrolled hypertension (blood pressure [BP] ≥150/95 mmHg despite medical therapy).

Mean resting correct QT interval (QTcF) >470 msec for women and >450 msec for men at
Screening, obtained from 3 ECGs using the screening clinic ECG machine derived QTcF value.

Any factors that may increase the risk of QTcF prolongation or risk of arrhythmic events
such as heart failure, chronic hypokalaemia not correctable with supplements, congenital or
familial long QT syndrome, family history of unexplained sudden death under 40 years of age
in first-degree relatives or any concomitant medication known to prolong the QT interval
and cause Torsade de Pointes.

Any clinically important abnormalities in rhythm, conduction or morphology of resting ECGs,
eg, complete left bundle branch block, third degree heart block, second degree heart block,
P-R interval >250 msec.

Acute coronary syndrome

- Wide field radiotherapy (including therapeutic radioisotopes such as strontium 89)
administered ≤28 days or limited field radiation for palliation ≤7 days prior to
starting study drug or has not recovered from side effects of such therapy.

- Major surgical procedures ≤28 days of beginning study drug or minor surgical
procedures ≤7 days

- Evidence of severe or uncontrolled systemic diseases, including renal transplant,
active bleeding diatheses or uncontrolled hypertension, which in the investigator's
opinion makes it undesirable for the patient to participate

- Active hepatitis B or C or known serious active infection e.g. tuberculosis or human
immunodeficiency virus. Viral testing is not required for assessment of eligibility
for the study.

- Known serious active infection including, but not limited to, tuberculosis, or human
immunodeficiency virus (positive human immunodeficiency virus 1/2 antibodies).

- Presence of other active cancers, or history of treatment for invasive cancer, within
the last 5 years. Patients with Stage I cancer who have received definitive local
treatment at least 3 years previously, and are considered unlikely to recur are
eligible. All patients with previously treated in situ carcinoma (ie, non-invasive)
are eligible, as are patients with history of non-melanoma skin cancer.

- Spinal cord compression or brain metastases unless asymptomatic, stable and not
requiring steroids for at least 2 weeks prior to start of study treatment.

- Past medical history of interstitial lung disease(ILD), drug-induced ILD, radiation
pneumonitis which required steroid treatment, or any evidence of clinically active

- History of liver cirrhosis of any origin and clinical stage; or history of other
serious liver disease or chronic disease with relevant liver involvement, with or
without normal LFTs,

- Prior or current treatment with a 3rd generation EGFR-TKI other than osimertinib

- Prior or current treatment with savolitinib or another MET inhibitor (eg, foretinib,
crizotinib, cabozantinib, onartuzumab, capmatinib).

- Any cytotoxic chemotherapy, investigational agents or other anticancer drugs for the
treatment of advanced NSCLC from a previous treatment regimen or clinical study within
14 days prior to the first dose of study treatment with the exception of monotherapy
osimertinib which may continue uninterrupted during screening.

- Patients currently receiving (or unable to stop use prior to receiving the first dose
of study treatment) medications or herbal supplements known to be strong inducers of
CYP3A4, strong inhibitors of CYP1A2 within 3 weeks of the first dose of study
treatment (including St John's Wort).

- Participation in another clinical study with a cytotoxic, investigational product
(IP), or other anticancer drug for the treatment of advanced NSCLC if received IP from
that study within 14 days of the first dose of study treatment.

- Known hypersensitivity to the active or inactive excipients of osimertinib or
savolitinib or drugs with a similar chemical structure or class.

Note: Other protocol defined Inclusion/Exclusion criteria may apply.

Eligibility last updated 8/22/22. Questions regarding updates should be directed to the study team contact.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Konstantinos Leventakos, M.D., Ph.D.

Open for enrollment

Contact information:

Cancer Center Clinical Trials Referral Office

(855) 776-0015

More information


Publications are currently not available

Additional contact information

Cancer-related trials contact form

Phone: 855-776-0015 (toll-free)

International patient clinical studies questions