A Study to Assess Carotid Blood Velocity Using Continuous Wave Doppler during Lower Body Negative Pressure


About this study

The purpose of this study is to determine the changes in carotid blood flow velocity during graded degrees of hypotension with lower body negative pressure (LBNP) using a portable Doppler developed by Flosonics.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • 15 healthy individuals aged ≥ 18 years.
  • No history of cardiovascular diseases.
  • Current non-smokers.
  • All subjects will be informed about the study and consented prior to participation

Exclusion Criteria:

  • Subjects with a history of more significant hypotension (SBP < 90mmHg).
  • Subjects who are morbidly obese (BMI > 38).


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Bruce Johnson, Ph.D.

Open for enrollment

Contact information:

Briana Ziegler



More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available