A Study of the Effects of Cytochrome P450 Enzyme on the Metabolism of Nimodipine after Aneurysm

Overview

About this study

The purpose of this study is to determine if cytochrome P450 (CYP) enzyme family variants alter the body's metabolism of nimodipine after Aneurysmal Subarachnoid Hemorrhage (aSAH), and if actual levels of nimodipine correlate with clinical events and patient outcomes.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Male and female spontaneous intracerebral hemorrhage (ICH) patients.
  • >18 years of age.
  • Admitted to the Neuroscience Intensive Care Unit (NeuroICU) at Mayo Clinic Florida.
  • Intracranial aneurysm documented by computed tomography (CT) angiogram, formal cerebral angiogram or magnetic resonance (MR) angiogram and deemed to be the cause of the SAH by the treating NeuroICU attending or Neurosurgeon.
  • External ventricular drain (EVD) placed as standard of care for management of symptomatic hydrocephalus by the treating neurosurgeon The EVD must also be deemed functional by the surgeon to allow for sampling of CSF via aseptic, sterile technique.
  • Arterial catheter placed standard of care.
  • Modified Fisher scale severity of bleeding grade 3 or 4.

Exclusion Criteria: 

  • Pregnant females.
  • Non-aneurysmal subarachnoid hemorrhage (e.g., traumatic or perimesencephalic SAH defined by negative formal cerebral angiogram, CT angiogram, and clinical documentation).
  • EVD is not placed, or non-functional EVD that does not allow for CSF drainage. However, if a subsequent EVD is placed that is functional, the patient may become eligible.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

William Freeman, M.D.

Open for enrollment

Contact information:

Rosita Almira

Almira.Rosita@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

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