A Study of the Effects of Cytochrome P450 Enzyme on the Metabolism of Nimodipine after Aneurysm

Overview

About this study

The purpose of this study is to determine if cytochrome P450 (CYP) enzyme family variants alter the body's metabolism of nimodipine after Aneurysmal Subarachnoid Hemorrhage (aSAH), and if actual levels of nimodipine correlate with clinical events and patient outcomes.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Male and female spontaneous aSAH patients  admitted to the Neuroscience Intensive Care Unit (NeuroICU) at Mayo Clinic Florida
  • ≥ 18 years of age.
  • Intracranial aneurysm documented by computed tomography (CT) angiogram, formal cerebral angiogram or magnetic resonance (MR) angiogram and deemed to be the cause of the SAH by the treating NeuroICU attending or Neurosurgeon. Alternatively initially angiogram negative SAH suspicious for other vascular cause including pretruncal/perimesencephalic, suspect arteriovenous malformation (AVM) or dural AV fistula may be included.
  • Ability to draw repeated blood samples via arterial, central or other venous line, and possibly timed with CSF draws via an external ventricular drain (EVD) if placed as standard of care for management of symptomatic hydrocephalus by the treating neurosurgeon. The EVD must be deemed functional by the surgeon to allow for sampling of CSF via aseptic, sterile technique or the drip chamber. Similarly, if a lumbar drain (LD) is placed by the treating neurosurgeon and/or neurointensivist team and functional this can be used to acquire CSF samples.
  • Modified Fisher scale severity of bleeding grade 3 or 4.

Exclusion Criteria: 

  • Traumatic SAH.
  • Pregnant or breastfeeding females.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

William Freeman, M.D.

Open for enrollment

Contact information:

Rosita Almira

Almira.Rosita@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available