Inclusion Criteria:

• Women age 18 years or older.
• Able to provide a written informed consent and who understand and agree to all study procedures required.
• A newly diagnosed adnexal mass was confirmed by imaging (computed tomography, ultrasonography, or magnetic resonance imaging) prior to enrollment.
• Planned diagnostic procedure or surgery by the subject’s physician to remove adnexal masses within 90 days of imaging. (Note that diagnostic procedure typically includes biopsy (needle core or laparoscopic-directed), ascites cytology, pleural effusion cytology or FNA).
• or
• Women with newly diagnosed clinically benign adnexal mass(es) for whom surgery is not planned as determined by the treating physician.

Exclusion Criteria:

• Had/Has a diagnosis of invasive malignancy (exception: non-melanoma skin cancers) in the previous 5 years.
• Currently receiving or ever received any of the following prior cancer therapies in the previous 5 years: curative surgical resection, local or systemic chemotherapy, targeted therapy, immunotherapy including cancer vaccines, hormone therapy, or radiation therapy.
• Pregnancy (by self-report of pregnancy status).
• Current febrile illness.
• Acute exacerbation or flare of an inflammatory condition requiring escalation in therapy.
• Recipient of organ transplant or prior non-autologous (allogeneic) bone marrow or stem cell transplant.
• Poor health status or unfit to tolerate blood draw.