A Study to Evaluate MR of CSF Dynamics


About this study

The purpose of this study is to evaluate changes in CSF dynamics (e.g., velocity, flow rate) between patients with normal pressure hydrocephalus and healthy controls, as well as patients with other dementia disorders.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • A healthy control will be defined as an otherwise healthy person who does not have a medical condition that affects brain function or have problems with concentration, memory, balance, or coordination.
  • Patients who have a suspected diagnosis of altered CSF dynamics including but not limited to normal pressure hydrocephalus will be referred to Dr. Cogswell by their care team to be included in the study. 
  • Conditions of altered CSF dynamics include obstructive and non-obstructive hydrocephalus and may be associated with headaches and/or decreased cognitive function.
  • Similarly, patient’s with impaired cognitive function including, but not limited to, Alzheimer’s disease will be referred to Dr. Cogswell by their care team to be included in the study.

Exclusion Criteria: 

  • Subjects with non-MRI compatible devices.
  • Subjects with required sedation.
  • Women who may be pregnant.


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Petrice Cogswell, M.D., Ph.D.

Open for enrollment

Contact information:

Suson Walsh CCRP

(507) 293-0039


More information


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