A Study to Investigate the Use of Diaphragm Muscle Ultrasound to Assess the Duration of a Diaphragm Nerve Block


About this study

The purpose of this study is to to determine the impact of anesthesia (liposomal bupivacaine) on diaphragm muscle forces using a non-invasive ultrasonographic shear wave elastography (SWE) method.  

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adult patients (18 years of age and older).
  • Undergoing shoulder arthroplasty.
  • Have consented to interscalene blockade for postoperative analgesia.

Exclusion Criteria: 

  • Patient refusal.
  • Contraindications of interscalene blockade due to patient factors such as: significant pulmonary insufficiency, pre-existing hemidiaphragmatic paralysis, brachial plexus or degenerative neuropathy, allergy to proposed local anesthetic medication, severe cervical spine disease, BMI >40 kg/m2, neck circumference >50cm, pre-existing thoracic/diaphragmatic operations, and failed preoperative interscalene blockade.
  • Patient is pregnant and/or breastfeeding.
  • Patient is unable to provide informed consent.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Carlos Mantilla, M.D., Ph.D.

Open for enrollment

Contact information:

Carlos Mantilla M.D., Ph.D.



More information


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