A Study to Evaluate the Development and Validation of Disaccharidase Determination from Small Bowel Biopsy Specimens.

Overview

About this study

The purpose of this study is to prospectively collect a microscopic biopsy from individuals who have a clinical suspicion of a possible gastrointestinal disaccharidase deficiency, and to develop and validate clinical enzymatic assays for intestinal disaccharidase lactase, palatinase, sucrase, maltase, or glucoamylase (Disaccharidase Enzyme Panel) in order to detect deficiencies in these enzymes, thereby benefiting the diagnosis of gastrointestinal disorders at Mayo Clinic.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients less than age 18 years old.
  • Patients with known or suspected gastrointestinal disorder associated with malfunction of intestinal disaccharidases.

Exclusion Criteria: 

  • All others.

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Devin Oglesbee, Ph.D.

Open for enrollment

Contact information:

Biochemical Genetics Laboratory Genetic Counselor

(507)266-4996

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available