A Study to Evaluate the Relationship of the Glucose Threshold for Insulin Secretion with Beta-cell Function

Overview

About this study

The purpose of this study is to determine if the set-point for fasting insulin secretion, and the subsequent response to hyperglycemia, is altered in people with IFG with or without accompanying IGT.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Up to 60 weight-stable, non-diabetic subjects from Biobank participants at Mayo Clinic, Rochester will be recruited.
  • Potentially eligible subjects who express a desire to be contacted by the research team will be invited to meet with the PI and / or another member of the study team.
  • Interested subjects will come to the Clinical Research Trials Unit for a screening visit.

Exclusion Criteria: 

  • Age < 25 or > 65 years old (to avoid studying subjects who could have latent type 1 diabetes, or the effects of age extremes in subjects with normal or impaired fasting glucose).
  • HbA1c ≥ 6.5%.
  • Use of glucose-lowering agents.
  • For female subjects: positive pregnancy test at the time of enrollment or study.
  • History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
  • Active systemic illness or malignancy.
  • Symptomatic macrovascular or microvascular disease.
  • Hormone therapy >0.625 mg premarin daily.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Adrian Vella, M.D.

Open for enrollment

Contact information:

Paula Giesler R.N.

(507) 255-8345

Giesler.Paula@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available