Enhanced, EHR-facilitated Cancer Symptom Control (E2C2) Pragmatic Clinical Trial 


About this study

The Enhanced, EHR-facilitated Cancer Symptom Control (E2C2) Pragmatic Clinical Trial will determine whether systematically assessing patient reported outcomes for sleep disturbance, pain, anxiety, depression, and fatigue among patients with solid and liquid malignancies and using these data to increase the frequency of guideline-concordant care by: 1) reporting these data to their clinical teams, 2) providing patients with needs-matched symptom self-management education, and 3) suggesting evidence-based symptom management strategies to their care teams improves patients' quality of life, symptoms, and adherence to cancer treatment, while reducing their unplanned use of healthcare resources.


Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Undergoing treatment, or have undergone treatment, for cancer at a Mayo Clinic Midwest medical oncology clinic.

Exclusion Criteria:

  • Lack of English fluency.
  • Membership in a vulnerable population - prisoner.
  • Membership in a vulnerable population - mentally handicapped.
  • Membership in a vulnerable population - Axis I psychiatric condition.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Andrea Cheville, M.D.

Closed for enrollment

Contact information:

Andrea Cheville M.D.

(507) 284-2747


More information


Publications are currently not available

Additional contact information

Cancer-related trials contact form

Phone: 855-776-0015 (toll-free)

International patient clinical studies questions