Randomized Control Trial for Awake vs. Asleep Craniotomy for Non-eloquent Gliomas


About this study

The purpose of this study is to compare local and general anesthesia (Awake vs. Asleep Craniotomy) in the removal of brain tumors that are in areas of the brain that do not directly control bodily functions (non-eloquent gliomas).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Patients with age ≥18 years old.
  • WHO grade I, II, III, and IV Glioma in non-eloquent brain cortex based on magnetic resonance imaging (MRI) and determined by an independent brain surgeon (Dr. Ron Reimer).
  • An elective procedure.
  • A single lesion.
  • No major comorbidities that would necessitate an extended hospital stay.
  • Newly diagnosed tumors.

Exclusion Criteria:

  • Patients with age < 18 years old.
  • Non-gliomas.
  • Eloquent location (motor, sensory, language).
  • Non-elective procedure.
  • Multiple lesions.
  • Major comorbidities.
  • Recurrent tumors.
  • Patients lacking capacity to consent.


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Jacksonville, Fla.

Mayo Clinic principal investigator

Kaisorn Chaichana, M.D.

Closed-enrolling by invitation

What is this? (?)
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Elizabeth Martin B.S., M.S.

(904) 953-2800


More information


Publications are currently not available

Additional contact information

Cancer-related trials contact form

Phone: 855-776-0015 (toll-free)

International patient clinical studies questions