A Study to Determine the Best Individualized Cancer Therapy Using Circulating Tumor DNA (ctDNA) in Patients with GI, CNS, and Thoracic Cancers.
Overview
Tab Title Description
Study type
InterventionalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Jacksonville, Florida: 17-011000
Sponsor Protocol Number: 17-011000
About this study
This study proposes to develop and maintain a biorepository of blood samples collected from patients receiving definitive chemoradiotherapy for locally advanced rectal cancer, locally advanced pancreatic cancer, non-small cell lung cancer, or cervical cancer. The ultimate goal of this biorepository will be to provide the resource to initiate an exploration of ctDNA as a potential liquid biopsy for GI and Thoracic malignancy detection and surveillance.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
- Adult patients (> 18 years of age) receiving definitive chemoradiotherapy at Mayo Clinic Florida
- Patients with tumors with a risk of local persistence of disease after therapy in the following areas:
- Locally advanced rectal cancer (T3-4NxM0; TxN+M0)
- Locally advanced non-small cell lung cancer
- Locally advanced pancreatic cancer
- High grade brain and spine tumors
- Locally advanced cervical cancer treated with primary radiotherapy
Exclusion Criteria:
- Adult patients not willing/able to provide informed consent
- Patients <18 years of age
- Patients with HIV infection or Hepatitis infection
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
Contact |
Jacksonville, Fla.
Mayo Clinic principal investigator Byron May, M.D. |
Open for enrollment |
Contact information:
Anna Harrell B.S., M.P.H., CCRP
Harrell.Anna@mayo.edu
|
More information
Publications
Publications are currently not available
Study Results Summary
Not yet available
Supplemental Study Information
Not yet available