A Study of Neurodevelopmental Abnormalities in Children Exposed to Anesthesia Prior to Age 3


About this study

The purpose of this study is to determine if neurodevelopmental abnormalities in children exposed to anesthesia prior to age 3 are associated with specific changes in brain MRI.  Individuals who have already undergone detailed neuropsychological testing as part of an earlier study will be invited to return for brain imaging.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Subjects will be sampled from the 997 subjects who underwent neuropsychological testing in the current funding period.
    • Most are still resident in Olmsted County, MN or environs.

Exclusion Criteria: 

  • Claustrophobia or other condition which precludes the subject from lying quietly in the MRI scanner 
  • Standard MRI contraindications such as an implanted device, and
  • Oral braces or other head and neck metal implants that significantly degrade MRI image quality

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

David Warner, M.D.

Closed-enrolling by invitation

What is this? (?)
Not open to everyone who meets the eligibility criteria, but only those invited to participate by the study team.

Contact information:

Brenda Anderson R.N.



More information


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