Validation of Cognitive Tests in Elderly Cirrhotic Patients

Overview

About this study

The purpose of this study is to define the prevalence and impact of cognitive impairment and their impact on HRQOL in elderly patients with cirrhosis compared to elderly patients without cirrhosis.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Please contact the study team to discuss whether or not you are eligible to participate in a study.

Inclusion Criteria

Group 1: Elderly Controls

  • Age Between 65 and 95 with Preserved activities of daily living
  • Able to give consent for study
  • MME_>25
  • Without Evidence of MCI and/or Chronic Liver Disease/cirrhosis

Group 2: Elderly Cirrhosis

  • Age Between 65and 95 years
  • Able to give consent
  • Clinically or biopsy proven cirrhosis

Exclusion Criteria:

Group 1: Elderly Controls

  • Unable to give informed consent
  • Alcohol/illicit drug abuse within 3 months
  • History of mental illness disorders (bipolar, schizophrenia, uncontrolled depression BDI>20, seizure disorder), cerebrovascular disease (stroke), progressive neurological diseases (severe neuropathy, Parkinson’s, Multiple sclerosis etc).  Serious liver (cirrhosis, hepatitis of any kind, fatty liver without >3 ULN AST and ALT ok), kidney (CKD > stage II), heart (any uncontrolled CAD, CHF, AFib and other serious arrhythmias), respiratory (COPD, IPF), endocrine (DM if last hemoglobin Aic >7.5), or metabolic diseases (osteoporosis is ok)
  • Current therapy with Galantamine and Aricept or other therapies directed for dementia
  • Use of anti-psychotics and any anti-seizure medications

Group 2: Elderly Cirrhosis

  • Not able to give consent
  • Alcohol and Illicit drug use within the last 3 months of study
  • TIPS within the last 3 months
  • Focal neurological deficits noted in the medical chart
  • Use of any anti-psychotics and anti-seizure medications
  • History of mental illness disorders (bipolar, schizophrenia, uncontrolled depression BDI>20, seizure disorder), cerebrovascular disease (stroke), progressive neurological diseases (severe neuropathy, Parkinson’s, Multiple sclerosis etc).  Serious kidney (CKD > stage II), heart (any uncontrolled CAD, CHF, AFib and other serious arrhythmias), respiratory (COPD, IPF), endocrine (DM if last hemoglobin Aic >7.5), or metabolic diseases (osteoporosis is ok).

 

 

 

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Hugo Vargas, M.D.

Closed for enrollment

Contact information:

Megan Kelly M.H.A.

(480) 342-1248

Kelly.Megan1@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

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