Effects of Ischemia and Hypoxia on Exercise Tolerance and the Development of Quadriceps Fatigue in Men and Women


  • Study type

  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 17-008737
    Sponsor Protocol Number: 17-008737

About this study

The goal of this study is to determine how neuromuscular fatigue in exercising muscle is influenced by local vs. global oxygen deficit. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

  • Non-obese healthy male and female
  • non-smoking participants
  • 18-40 years old with no significant metabolic, cardiovascular, neurologic disease and no contraindications to exercise, as determined by the principle investigator

Exclusion Criteria:

  • Those taking medications that might influence the cardiovascular, respiratory or neuromuscular responses to exercise will also be excluded, on the discretion of the principle investigator (e.g. beta blockers and some other antihypertensives along with anti-asthma drugs)
  • Any subjects with a recent injury to their dominate leg/knee
  • Subjects will also be excluded if they have any metal in their groin area.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Michael Joyner, M.D.

Open for enrollment

Contact information:

Shelly Roberts R.N.



More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available