A Study of Specialized Systems in the Brain and How They Relate to the Disease Processes in aMCI and AD


About this study

This study is being done to learn more about specialized systems in the brain and how they relate to the disease processes in aMCI and AD.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Study subjects 41 years of age and older 
  • Subjects will be recruited through the Mayo Clinic ADRC and enrolled in existing research protocols
  • Healthy Volunteers 18 years of age or older

Exclusion Criteria: 

  • Subjects and a suitable informant will be interviewed by nurse clinicians who will complete a modified Clinical Dementia Rating (CDR) and Mayo Sleep Questionnaire to assess for REM sleep behavior disorder (RBD) in aging and dementia cohorts
  • RBD is highly associated with an underlying synucleinopathy and is therefore used as an exclusionary criterion in this study of typical AD


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

David Jones, M.D.

Closed for enrollment

Contact information:

Alzheimer’s Disease Research Center

(507) 284-1324

More information


Publications are currently not available