Real-Time Myocardial Perfusion Echocardiography in the ICU


About this study

This study is being done to find out if and how much the use of RTMPE improves a provider's confidence in the diagnosis they assign. This is important because the use of RTMPE may decrease the need for any additional invasive testing.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  1. Adults age ≥ 18 years
  2. Located in a designated ICU
  3. TTE ordered by the primary care team
  4. Significant delta in troponin trend
  5. Concern for myocardial ischemia
  6. Women of child-bearing potential must have a clinical negative pregnancy test result
  7. Experienced sonographer available to complete RTMPE portion of the exam
  8. Provider willing to complete the study survey

Exclusion Criteria:

  1. Adults < 18 years
  2. Contraindication to echo contrast administration
  3. Location other than an ICU
  4. No significant delta in troponin trend

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Patricia Pellikka, M.D.

Closed for enrollment

Contact information:

Patricia Pellikka M.D.

(507) 266-1376

More information


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