The Ventilatory Response to Activation of the Locomotor Afferents in Normoxic and Hypoxic Conditions
Tab Title Description
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
- Rochester, Minnesota: 12-005040
Sponsor Protocol Number: 12-005040
About this study
The purpose of this study is two-fold. The first purpose is to understand how feedback from your muscles can change ventilation at rest and during exercise in low and high oxygen conditions. The second purpose is to understand how feedback from your muscles can influence muscle fatigue and muscle function in normal and low oxygen conditions. The ventilatory response to exercise and skeletal muscle fatigability in healthy controls and HF patients will advance our understanding of tolerance to exercise in HF patients.
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Heart Failure Patients
- >21 yrs
- No history of dangerous arrhythmia’s
- Not be pacemaker dependent
- Have a body mass index ≤35kg/m²
- Currently be non-smokers with <15 pack year history
- Able to exercise (i.e. without orthopedic limitations or musculoskeletal disorders).
- Healthy adults (≥18 years of age)
- No history of cardiovascular, pulmonary, metabolic, neurologic, orthopaedic, or other diseases affecting the neuromuscular system.
- Additional inclusion criteria include: BMI ≤35kg/m²
- Current non-smokers with smoking history <15 pack years
- Those who are able to engage in exercise (i.e. without orthopedic limitations or musculoskeletal disorders).
- Female participants cannot be pregnant or breast feeding.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
|Mayo Clinic Location
Mayo Clinic principal investigator
Thomas Olson, M.S., Ph.D.
Closed for enrollment
Publications are currently not available