Metabolomics of Portal Venous Blood for the Study of the Gut-liver Axis in Hepatobiliary Disease


About this study

The purpose of this study is to determine if there are differences in the metabolites (enzymes and other proteins) found in portal venous blood (blood in the portal vein, which delivers blood from the intestines to the liver), peripheral venous blood, and bile between individuals with liver disease undergoing liver transplantation and healthy donors. With this information, we may be able to better understand the importance and nature of the relationship between the gut (i.e. intestines) and the liver in the context of liver disease and identify pathways which may lead to the development of new and improved therapies for patients with liver disease. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Age 18 and older
  • Men and women
  • Primary sclerosing cholangitis (PSC) subjects scheduled for liver transplantation (LT)
    • Controls will be their liver donor

Exclusion Criteria: 

  • Age 17 and younger
  • Not having primary sclerosing cholangitis (PSC) or not scheduled for an liver transplantation (LT)

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Steven OHara, Ph.D.

Open for enrollment

Contact information:

M Felmlee Devine CCRP

More information


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