New-onset Atrial Fibrillation and Flutter Following Cardiac Surgery


About this study

The aims of this investigation are:

To assess the predictive value (and accuracy) of clinical and physiologic preoperative variables in identifying patients at risk for the development of new-onset atrial arrhythmia after cardiac surgery.

To assess the feasibility of a physiological risk model based on clinical and echocardiographic indexes to predict post-operative AF.

To assess the role of prophylactic agents in the prevention of new-onset postoperative POAF

To assess the economic impact of new-onset postoperative AF:

  • Length of hospital stay (will be measured as fractions of days)

  • Hospital cost (will be measured in standardized dollars)

  • Resource utilization (will be measured by resource-based relative-value units)

To assess the outcome of patients who develop early atrial fibrillation following cardiac surgery:

  • To assess whether first time new-onset POAF predicts long-term AF.

  • Examine the predictive value of potential preoperative variables in identifying patients at risk of developing

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion criteria:

  • This will be historical cohort study of all patients above the age of 18 with preoperative sinus rhythm who underwent cardiac surgery, including Transcatheter Aortic Valve Replacement (TAVR) at the Mayo Clinic between 1990 and 2013.

    Exclusion criteria:

    • Patients who have denied research access to their medical records will not be included in the study (Minnesota state law [Minn Stat 144.335 subd. 3a (d)]).Since the study involves minimal risk to the patients, we will request waiver of informed consent and use HIPAA authorization.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Rowlens Melduni, M.D., M.P.H.

Closed for enrollment

Contact information:

Rowlens Melduni M.D., M.P.H.


More information


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