The Effects of Acute and Chronic Exercise on the Immune Phenotype in Healthy Patients


About this study

We are doing this study to compare how acute maximal and acute endurance exercise affect immune cell populations in the blood for different populations of healthy participants (comparing age, gender, fitness level, etc). We hope to use this information to develop a baseline understanding of how exercise affects immune system function.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion criteria

For aim 1-2: For the healthy controls, non-smoking individuals with a sedentary lifestyle (<60 mins of moderate intensity aerobic exercise per week, VO2 max < 80% of age predicted) and active lifestyle (>300 mins of moderate to high intensity aerobic exercise per week or VO2 max > 120% of age predicted.) The groups will be matched for age, sex, and BMI.

For Aim 3: participants will be recruited by their participation in the endurance or ultraendurance events selected by the study team.

Exclusion criteria

Healthy Controls

Subjects will be excluded if they have cardiovascular or pulmonary disease or autoimmune diseases. A pregnancy test will be used to screen women and those pregnant will be excluded. In addition, subjects will not be allowed to participate if they currently smoke or have had a significant history of smoking (>5 pack years).

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Bruce Johnson, Ph.D.

Closed for enrollment

More information


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Study Results Summary

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Supplemental Study Information

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Additional contact information

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Phone: 800-664-4542 (toll-free)

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