Stress Management and Resiliency Training (SMART) Integrated Into Treatment of Major Depression


About this study

The investigators are doing this research study to find out if the Stress Management and Resiliency Training (SMART) therapy will help subjects with their major depression treatment.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Attending the Mayo Clinic Depression Center and Behavioral Health Clinic at Mayo Clinic Health System, Austin, Minnesota
  • DSM-V diagnostic confirmation of major depressive disorder (MDD)
  • Baseline PHQ-9 scores in the range of ≥6-≤19, and HAMD-17 score 8-18, or QIDS-C16 score of 6-20
  • Able to speak English
  • Participants will continue taking any prescribed medications from their clinical treatment team
  • Patients with co-morbid secondary diagnoses of persistent depressive disorder and generalized anxiety disorders will be included in the study.

Exclusion Criteria:

  • Participants with bipolar disorder
  • Active psychosis
  • Active suicidal ideations
  • Active substance abuse meeting criteria for substance use disorders except nicotine
  • Obsessive compulsive disorder
  • Active Panic disorder with agoraphobia, other phobic disorder
  • Active Posttraumatic stress disorder
  • Active Severe personality disorders.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Austin, Minn.

Mayo Clinic principal investigator

Ashok Seshadri, M.D.

Closed for enrollment

Rochester, Minn.

Mayo Clinic principal investigator

Ashok Seshadri, M.D.

Closed for enrollment

More information


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Additional contact information

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